![]() Leptomeningeal enhancement is uncommon but encountered either in isolation or along with cortical lesions (e.g. Deep grey matter and brainstem involvement is more common in children 6. When present, lesions tend to be few in number but sizable, typically bilateral with ill-defined borders. Cerebral involvementĪcute disseminated encephalomyelitis (ADEM) is a common presenting clinical and imaging phenotype of patients with MOGAD, particularly in childhood 6. In contrast, less than half of adults presenting with MOGAD have brain lesions at the time of diagnosis. Nonetheless, certain imaging features are increasingly recognized as being more typical of MOGAD, allowing the diagnosis to be suspected on the basis of imaging. acute disseminated encephalomyelitis (ADEM), neuromyelitis optica spectrum disorder (NMOSD) and to a lesser degree multiple sclerosis). Imaging presentation of MOGAD is variable and with no pathognomonic imaging features, with patients having an imaging phenotype often indistinguishable from other inflammatory white matter diseases of the central nervous system (e.g. Myelin oligodendrocyte glycoprotein (MOG) is expressed on oligodendrocytes and the outer lamellae of myelin sheaths 6. 2022) no single set of diagnostic criteria are universally accepted 5. No specific presentation distinguishes individuals with anti-MOG antibodies from those presenting with similar clinical manifestation but without the antibodies and at the time of writing (c. This may include a CLIPPERS-like presentation 9,10 Transverse myelitis (30%) including conus medullaris syndromeĪssociated with longitudinally extensive spinal cord lesionsĪssociated with FLAIR-hyperintense lesions in anti-MOG associated encephalitis with seizures (FLAMES) 7 This may encompass cases previously termed chronic relapsing inflammatory optic neuropathy (CRION) Not all presentations are equally prevalent: In approximately half of cases there is viral prodrome 2. Neurological update: MOG antibody disease.Clinical presentation is similar to that of other acquired demyelinating conditions and varies from individual to individual. MOG antibody demyelination: Information for patients.Emerging drugs for the treatment of adult MOG-IgG-associated diseases. ![]() Clinical features and risk of relapse in children and adults with myelin oligodendrocyte glycoprotein antibody-associated disease. Myelin oligodendrocyte glycoprotein antibody-associated disease: Current insights into the disease pathophysiology, diagnosis, and management. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. muscle weakness or paralysis, particularly in the arms and legsĪcute disseminated encephalomyelitis (ADEM)ĪDEM is an inflammatory condition that affects the brain.abnormal sensations, which can include feelings of numbness and tingling (“pins and needles”) and extreme sensitivity to touch.The exact symptoms of transverse myelitis can vary depending on which part of the spinal cord is affected. Transverse myelitis is when inflammation affects the spinal cord. eye pain, particularly when moving your eye.This nerve transmits signals between your eyes and your brain. Optic neuritis is inflammation of the optic nerve. It’s been associated with the following conditions: Optic neuritis MOGAD can affect parts of the nervous system like the optic nerve, spinal cord, and brain.
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